For example: Fatigue, unexplained weight loss, or abdominal pain may indicate liver disease or cancer Easy bruising, night sweats, or feeling full quickly (early satiety) may suggest a myeloproliferative disorder Swelling in the legs, reduced urine output, or persistent nausea may point to kidney disease In cases of very high B12 from injections (not oral supplements), some people have reported headache, nausea, diarrhea, facial flushing, or skin rash
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A worsening reaction could indicate a true allergy to the medication itself, which can develop even after initial tolerance
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Ongoing research suggests the medications could have other positive impacts, including reduced risks of cardiovascular disease and some cancers
Representative preclinical and clinical studies of myo-inositol-based interventions in PCOS are summarized in Table 2
